KIR2DL4 antibody [mAb#33] (PE-Cy5)

Catalogue Number: GTX80038-09-GTX

Manufacturer:	GeneTex
Preservative:	15 mM Sodium azide
Molecular Weight:	41
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CD158D , G9P , KIR , KIR103 , KIR103AS , KIR2DL4 , killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Shipping Condition:	Blue Ice
Unit(s):	100 tests
Host name:	Mouse
Clone:	mAb#33
Isotype:	IgG1
Immunogen:	NK3.3 cells and KIR2DL4-Ig fusion protein
Application:	FC

Overview
Datasheets

Description

Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]

Additional Text

Gene Name

KIR2DL4

Uniprot ID

Q99706

Gene ID

3805

Antibody Clonality

Monoclonal

Purification

Size-exclusion Chromatography

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. Cy and CyDye are trademarks of GE Healthcare.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. DO NOT FREEZE. Protect from light.

Application Notes

FCM: 4 µl reagent / 100 µl of whole blood or 10⁶ cells in a suspension. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX80038-09 Datasheet

Price

£330.00

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Quantity
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