c-Abl (phospho Tyr412) antibody

Catalogue Number: GTX81938-GTX

Manufacturer:	GeneTex
Preservative:	0.09% sodium azide
Molecular Weight:	123
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	ABL proto-oncogene 1, non-receptor tyrosine kinase , ABL , CHDSKM , JTK7 , bcr/abl , c-ABL , c-ABL1 , p150 , v-abl
Shipping Condition:	Blue Ice
Unit(s):	400 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y412 of human c-Abl.
Application:	IHC-P, WB, DB

Overview
Datasheets

Description

Description: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

Additional Text

Gene ID

Gene Name

ABL1

Uniprot ID

P00519

Modification

Phosphorylated, Tyr412

Molecular Weight

123

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Purification

Affinity Purified; Protein A Purified

Application Notes

WB: 1:1000. IHC-P: 1:50-1:100. Dot: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX81938 Datasheet

Price

£410.00

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Quantity
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