CD45 antibody
Catalogue Number: GTX82139-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide|0.02% Sodium azide |
| Molecular Weight: | 147 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | protein tyrosine phosphatase receptor type C , B220 , CD45 , CD45R , GP180 , L-CA , LCA , LY5 , T200 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Chicken |
| Clone: | |
| Isotype: | IgY |
| Immunogen: | Immunogen Sequence: GI # 18641347, sequence 482-552 Recombinant protein tyrosine phosphatase, receptor type, C isoform 1 |
| Application: | WB |
Description
Description: Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity. while the second one seems to affect the substrate specificity of the first one. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth. differentiation. mitotic cycle. and oncogenic transformation. This PTP contains an extracellular domain. a single transmembrane segment and two tandem intracytoplasmic catalytic domains. and thus belongs to receptor type PTP. This protein is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes. or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases. and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene. which encode distinct isoforms. have been reported.
Additional Text
Gene Name
PTPRC
Gene ID
5788
Uniprot ID
P08575
Purification
Affinity Purified
Molecular Weight
147
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX82139 Datasheet
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