LDL Receptor antibody
Catalogue Number: GTX85109-GTX
GTX85109 Image
GTX85109 Image
GTX85109 Image
GTX85109 Image
IHC-P analysis of human liver tissue using GTX85109 LDL Receptor antibody. Working concentration : 2.5 µg/ml
GTX85109 Image
IHC-P analysis of human liver tissue using GTX85109 LDL Receptor antibody. Working concentration : 20 µg/ml
GTX85109 Image
WB analysis of human liver tissue lysate using GTX85109 LDL Receptor antibody. Working concentration : (A) 1 and (B) 2 µg/ml
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide|0.02% Sodium azide |
| Molecular Weight: | 95 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | low density lipoprotein receptor , FH , FHC , LDLCQ2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Chicken |
| Clone: | |
| Isotype: | IgY |
| Immunogen: | LDL-R antibody was raised against an 18 amino acid synthetic peptide near the center of human LDL-R.The immunogen is located within amino acids 490 - 540 of LDL-R. |
| Application: | ELISA, IHC-P, WB |
Description
Description: The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
Additional Text
Gene Name
LDLR
Uniprot ID
P01130
Gene ID
3949
Purification
Affinity Purified
Molecular Weight
95
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Concentration
1 mg/ml
Application Notes
WB: 1 - 2 µg/mL. IHC-P: 2.5 µg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX85109 Datasheet
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