ALDH2 antibody, Internal

Catalogue Number: GTX88073-GTX

Manufacturer:	GeneTex
Preservative:	0.02% Sodium azide\|0.02% Sodium azide
Molecular Weight:	56
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	aldehyde dehydrogenase 2 family member , ALDH-E2 , ALDHI , ALDM
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Goat
Clone:
Isotype:	IgG
Immunogen:	Peptide with sequence C-DETQFKKILGYIN, from the internal region of the protein sequence according to NP_000681.2; NP_001191818.1.
Application:	ELISA, sELISA, WB

Overview
Datasheets

Description

Description: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]

Additional Text

Gene Name

ALDH2

Gene ID

217

Uniprot ID

P05091

Concentration

0.5 mg/ml

Molecular Weight

Purification

Ammonium Sulfate Precipitated; Affinity Purified

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 0.03-0.1µg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX88073 Datasheet

Price

£410.00

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Quantity
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