Von Hippel Lindau antibody, Internal
Catalogue Number: GTX89268-GTX
GTX89268 Image
GTX89268 Image
GTX89268 Image
GTX89268 Image
WB analysis of human ovary lysate using GTX89268 Von Hippel Lindau antibody, Internal. Dilution : 0.01µg/ml Loading : 35µg protein in RIPA buffer
GTX89268 Image
IHC-P analysis of human kidney using GTX89268 Von Hippel Lindau antibody, Internal. Antigen retrieval : citrate buffer pH 6 Dilution : 5µg/ml
GTX89268 Image
ELISA analysis of Von Hippel Lindau protein using GTX89268 Von Hippel Lindau antibody, Internal. Capture : GTX101087 (2.5µg/ml) Detection : GTX89268 (1.5µg/ml)
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide|0.02% Sodium azide |
| Molecular Weight: | 24 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | von Hippel-Lindau tumor suppressor , HRCA1 , RCA1 , VHL1 , pVHL |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Peptide with sequence C-RSLVKPENYRRLD, from the internal region of the protein sequence according to NP_000542.1; NP_937799.1. |
| Application: | ELISA, IHC-P, sELISA, WB |
Description
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Additional Text
Gene ID
7428
Uniprot ID
P40337
Molecular Weight
24
Gene Name
VHL
Concentration
0.5 mg/ml
Purification
Ammonium Sulfate Precipitated; Affinity Purified
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 0.01-0.03µg/ml. IHC-P: 5µg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX89268 Datasheet
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