Heat Shock Protein 90, alpha (HSP90a)

Catalogue Number: H1834-55-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
Type:	ChIP Validated Antibodies
Shipping Condition:	Blue Ice
Unit(s):	50 ug
Host name:	Rat
Clone:	4E128
Isotype:	IgG2a
Immunogen:	Purified Hsp90 isolated from human therapeutic orchiectomy specimens
Application:	FC, ICC, IP, ChIP, WB, IHC

Overview
Datasheets

Description

Description: The 90kD molecular chaperone family comprises several proteins including the 90kD heat shock protein, Hsp90 and the 94kD glucose-regulated protein, grp94 which are major molecular chaperones of the cytosol and of the endoplasmic reticulum. In mammalian cells there are at least two Hsp90 isoforms, Hsp90alpha and Hsp90beta which are encoded by separate genes. The amino acid sequence of human and yeast Hsp90alpha is 85% and 90% homologous to that of Hsp90beta respectively (3). All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions which have been shown to contain independent chaperone sites with different substrate specificity (4,5). These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cell's powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steroid receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90 (6). It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

HSP90AA1

Gene ID

3320

Uniprot ID

P07900

Specificity

Recognizes human HSP90 alpha at ~90kD. Species Crossreactivity: chicken

Purification

Protein G purified

Antibody Clonality

Monoclonal

H1834-55 Datasheet

Price

£426.00

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