Heparan Sulfate Proteoglycan (Perlecan, HSPG) (MaxLight 490)

Catalogue Number: H1890-93C-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	basement membrane-specific heparan sulfate proteoglycan core protein\|endorepellin (domain V region)\|HSPG\|perlecan proteoglycan\|PLC\|PRCAN\|SJA\|SJS\|SJS1
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rat
Clone:	10H3
Isotype:	IgG2a, kappa
Immunogen:	Heparan Sulfate Proteoglycan from EHS mouse tumor. Epitope: HSPG core protein.
Application:	ICC, IP, WB, IHC

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Heparan sulfate proteoglycans (HSPGs) are found on cell surfaces and in the extracelluar matrix of all mammalian tissues, particularly in the core of the basement membrane. HSPGs found in the brain are dystroglycan, N-syndecan, glypican, and perlecan. The composition of HSPGs differs in the protein core, and is thought to determine the location of HSPG in the cell membrane (syndecan and glypican) and extracellular matrix (perlecan and dystroglycan). The postulated functions of HSPG include cell proliferation, differentiation, adhesion, migration and morphogenesis. Heparan Sulfate Proteoglycan antibodies, in tissues, react strongly and uniformly with basement membranes. The reactivity is independent of the galactosaminoglycan moieties; therefore, the epitope is not sensitive to heparinase treatment.

Additional Text

Accession Number

NP_005520

Gene Name

HSPG2

Specificity

Recognizes human Heparan Sulfate Proteoglycan (Perlecan). Recognizes domain IV of the core protein of the large Heparan Sulfate Proteoglycan.

Purification

Protein G purified

Uniprot ID

P98160

Gene ID

3339

Antibody Clonality

Monoclonal

H1890-93C-ML490 Datasheet

Price

£1,070.00

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