Heterochromatin Protein 1, alpha (HP1a) (PE)

Catalogue Number: H2034-50A-PE-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Type:	ChIP Validated Antibodies
Alias:	antigen p25\|chromobox homolog 5 (HP1 alpha homolog, Drosophila)\|chromobox protein homolog 5\|epididymis luminal protein 25\|HEL25\|heterochromatin protein 1 homolog alpha\|heterochromatin protein 1-alpha\|HP1\|HP1 alpha homolog\|HP1A\|HP1-ALPHA\|HP1Hs alpha
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	5H13 (15.19s2)
Isotype:	IgG1
Immunogen:	GST fusion protein corresponding to residues 2-191 from human HP1a.
Application:	ChIP, WB, IHC

Overview
Datasheets

Description

Description: Heterochromatin protein 1 (HP1) is a family of heterochromatic adaptor molecules involved in both gene silencing and higher order chromatin structure. All three HP1 family members (alpha, beta and gamma) are primarily associated with centromeric heterochromatin; however, HP1b and gamma also localize to euchromatic sites in the genome. HP1 proteins are approximately 25kD in size and each contains a conserved amino-terminal chromodomain, followed by a variable hinge region and a conserved carboxy-terminal chromoshadow domain. The chromodomain facilitates binding to histone H3 tri-methylated on Lys9, a histone "mark" closely associated with centromeric heterochromatin. The variable hinge region binds both RNA and DNA in a sequence-independent manner. The chromoshadow domain mediates the dimerization of HP1 proteins, in addition to binding multiple proteins implicated in gene silencing and heterochromatin formation, including the SUV39H histone methyltransferase, the DNMT1 and DNMT3a DNA methyltransferases and the p150 subunit of chromatin-assembly factor-1 (CAF1).

Additional Text

Gene ID

23468

Gene Name

CBX5

Uniprot ID

P45973

Specificity

Recognizes human HP1a at ~29kD. Species Crossreactivity: mouse and most common vertebrates.

Purification

Protein G purified

Accession Number

NM_012117

Antibody Clonality

Monoclonal

H2034-50A-PE Datasheet

Price

£1,237.00

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