Anti-Human/Mouse HDAC1 (Clone 10E2) - Purified No Carrier Protein

Catalogue Number: H297-LET

Manufacturer:	Leinco Technologies, Inc
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 25 ug
Host name:
Clone:
Isotype:
Immunogen:
Application:	IF, IP, ChIP, WB

Overview

Description

Description: HDAC1 is a histone deacetylase that plays an important role in transcriptional regulation, cell cycle progression, and development1 as well as regulates major endothelial functions such as angiogenesis, inflammatory signalling, redox homeostasis, and nitric oxide signalling2. As part of a large multiprotein complex, HDAC1 deacetylates lysine residues on the N-terminal portion of core histones H2A, H2B, H3 and H41. In this capacity, HDAC1 is involved in chromatin remodelling, histone acetylation, and RNA polymerase II progression in transcribed regions. Additionally, HDAC1 deacetylates non-histone targets (NR1D2, RELA, SP1, SP3, STAT3, RELA, TSHZ3, SP proteins), and thereby regulates their function. HDAC1 is also required for repression of circadian genes (CLOCK-BMAL-1, PER1, and CRY1). Knockout of HDAC1 in mice causes impairment to cellular proliferation and death at embryonic day 9.53.

Additional Text

Purification

Purified

Antibody Clonality

Monoclonal

Concentration

1 mg/ml

Storage Note

This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Price

£204.00

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