HLA Class 1 Antigen ABC (HLA ABC, Major Histocompatibility Complex Class I A + B + C, MHC HLA ABC) (PerCP)

Catalogue Number: H6098-60D-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with PerCP.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	W6/32
Isotype:	IgG2a
Immunogen:	Membranes from human tonsillar lymphocytes
Application:	FC

Overview
Datasheets

Description

Description: HLA-A, B, and C are ~45kD transmembrane glycoproteins in the major histocompatibility complex I (MHC I) family. They contain three alpha domains in their extracellular regions. HLA molecules are expressed on nearly all nucleated cells in association with the 12kD beta 2-Microglobulin. This complex binds peptides derived from pathogenic cytosolic or extracellular proteins such as viral or microbial proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD8+ cytotoxic T cells. The activated cytotoxic T cell then kills the presenting cell. Mismatched MHC I alleles between a host and a donor lead to transplant rejection.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes human MHC class I, HLA-A, B, and C.

Purification

Protein A purified

Antibody Clonality

Monoclonal

H6098-60D Datasheet

Price

£780.00

-

Quantity
Unit Size

Find out about delivery