Huntingtin Protein, aa2703-2911 (Huntington Disease) (PE)
Catalogue Number: H7960-01-PE-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 3H2241 (HDC8A4) |
| Isotype: | IgG1 |
| Immunogen: | Recombinant protein corresponding to aa2703-2911 of human Huntingtin Protein. |
| Application: | IP, WB, IHC |
Description
Description: Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.
Additional Text
Gene Name
HTT
Uniprot ID
P42858
Gene ID
3064
Specificity
Recognizes an epitope corresponding to the human HDC region (2703-2911 amino acids) of the Huntingtin protein. Detects a 350kD band on Western Blots but also detects smaller degradation products of Huntingtin. Recognizes both denatured and native Huntingtin in human brain. The combined use of H7960-01, H7960 and H7960-01A demonstrate that huntingtin is enriched in neuronal cells in the brain. Species Crossreactivity: rabbit and mouse
Purification
Protein G purified
Antibody Clonality
Monoclonal
H7960-01-PE Datasheet
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