Anti-Human IL-17E (Clone 182203)
Catalogue Number: I-873-LET
| Manufacturer: | Leinco Technologies, Inc |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | RT |
| Unit(s): | 500 ug |
| Host name: | |
| Clone: | 182203 |
| Isotype: | |
| Immunogen: | |
| Application: | FC, WB, MC |
Description
Description: IL-17E, also known as IL-25, is a novel member of the IL-17 family of cytokines1 and a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses.2 IL-17E has a heterodimeric receptor. The receptor is composed of two subunits IL-17RA and IL-17RB. Although IL-17E only binds IL-17RB directly, both subunit receptors are essential for IL-17E functions. IL-17E induces activation of NF-κB and stimulates production of the proinflammatory chemokine IL-8. 1 IL-17E may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts and therefore has a role in asthma pathophysiology.3
Additional Text
Antibody Clonality
Monoclonal
Storage Note
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
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