Immunoglobulin-Like Transcript 2 (ILT2, CD85j) (Carboxyfluorescein)

Catalogue Number: I7502-70A-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 0.5% BSA, 0.09% sodium azide. Labeled with Carboxyfluorescein.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	7H15
Isotype:	IgG1
Immunogen:	Recombinant protein corresponding to Gly24-His458 from human ILT2/Cd85j, expresed in NS0 cells.
Application:	FC

Overview
Datasheets

Description

Description: ILT2, also known as LIR1, MIR7, and CD85j, is expressed on most monocytes, dendritic cells, and mature B cells. It is also expressed on small percentages of T cells and NK cells. ILT2 has four extracellular Ig-like domains and three cytoplasmic ITIMs. It functions as an inhibitory receptor that prevents cellular activation. ILT2 has been shown to bind classical (HLA-A and -B) and non-classical (HLA-G1, -E and -F) MHC class I molecules (MHC I). ILT2 also binds with high affinity to an MHC I paralog from human cytomegalovirus. Ligation of ILT2 by MHC I may function to poise cellular activation thresholds and inhibit various leukocyte effector mechanisms that are regulated by MHC I molecules on target cells.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene ID

10859

Gene Name

LILRB1

Uniprot ID

Q8NHL6

Specificity

Recognizes human ILT2/CD85j.

Purification

Protein G purified

Antibody Clonality

Monoclonal

I7502-70A Datasheet

Price

£612.00

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