Immunoglobulin-Like Transcript 3 (ILT3, CD85k) (Carboxyfluorescein)

Catalogue Number: I7502-75A-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 0.5% BSA, 0.09% sodium azide. Labeled with Carboxyfluorescein.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	7H17
Isotype:	IgG2a
Immunogen:	Recombinant protein corresponding to Pro17-His257 from human ILT3 expressed in NS0 cells.
Application:	FC

Overview
Datasheets

Description

Description: The immunoglobulin-like transcript (ILT) family of activating and inhibitory type immunoreceptors are expressed on many leukocyte subsets and function in the regulation of immune responses (1-3). This family was also named leukocyte Ig-like receptors (LIR) and monocyte/macrophage Ig-like receptors (MIR). ILTs share significant homology with killer cell Ig-like receptors (KIR). The ILT genes are located on human chromosome 19q13.4 in the leukocyte receptor complex that also includes the genes encoding KIRs (4). With the exception of ILT6, which is a soluble molecule, all ILT family members are type I transmembrane proteins having two or four extracellular Ig-like domains (2, 3). One subset of the ILT receptors (referred to as subfamily B of the LIRs) has long cytoplasmic tails containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that inhibit signaling events by recruiting SH2-containing protein tyrosine phosphatase-1. Another subset of the ILT receptors (referred to as subfamily A of the LIRs) contains activating receptors with short cytoplasmic regions that lack signal transduction motifs. These receptors contain a basic arginine residue within their transmembrane domains, which allows association with Fcg R, an immunoreceptor tyrosine-based activation motif (ITAM)-bearing signal adapter protein (1-3). ILT3, also known as Leukocyte Immunoglobulin-Like Receptor subfamily B member 4 (LILRB4) and Leukocyte Immunoglobulin-like Receptor 5 (LIR-5), is a type I membrane protein that functions as a receptor for class I MHC antigens. It contains cytoplasmic ITIM motifs and is involved in the down-regulation of immune responses.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene ID

11006

Gene Name

LILRB4

Uniprot ID

Q8NHJ6

Specificity

Recognizes human ILT3/CD85k. Crossreactivity: recombinant human ILT5/LILRB3/LIR3: 50% by direct ELISA.

Purification

Protein A purified

Accession Number

ABM86208

Antibody Clonality

Monoclonal

I7502-75A Datasheet

Price

£548.00

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