Insulin-Like Growth Factor I (IGF1, IGF I, IGF-I, IBP1, Mechano Growth Factor, MGF, Somatomedia C, Somatomedin C) (APC)
Catalogue Number: I7661-01X-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 10D244 (M23/ILG1-001) |
| Isotype: | IgG1 |
| Immunogen: | Biosynthetic Insulin-Like Growth Factor I. |
| Application: | RIA, FLISA |
Description
Description: Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor which stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Recombinant Human IGF-I is a single, nonglycosylated, 7.6kD protein containing 70 amino acid residues. Insulin-like growth factor 1 (IGF-I) is involved in regulation of neuronal growth and development in central and peripheral nervous system. It is known to protect neurons against cell death induced by amyloidogenic derivatives, glucose or serum deprivation through pathways involving AKT kinase and transcription factor FKHRL1 phosphorylation. Activation of the insulin-like growth factor system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like breast and thyroid cancers.
Additional Text
Specificity
Recognizes human IGF-I. Shows minimal crossreactivity with IGF-II, proinsulin, MSF and insulin.
Purification
Protein A purified
Antibody Clonality
Monoclonal
I7661-01X-APC Datasheet
SUPPORT
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PRODUCT
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DELIVERY
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