Insulin Receptor, alpha (IRa) (MaxLight 650)

Catalogue Number: I7661-25D-ML650-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	2Q222 (47-9)
Isotype:	IgG1
Immunogen:	IM-9 lymphocytes followed by purified insulin receptor.

Overview
Datasheets

Description

Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. The insulin receptor is a tetrameric transmembranous glycoprotein composed of two alpha subunits (120kD) and two beta subunits (90kD). The alpha subunits are disulfide linked, totally extracellular and are the insulin binding site. The beta subunits are transmembranous and contain an intracellular tyrosine kinase domain. The biological effects of insulin are mediated primarily through the insulin receptor. The interaction of insulin with the alpha-subunit of the insulin receptor activates the protein tyrosine kinase of the beta-subunit which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adaptor proteins, IRS-1, IRS-2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain-containing signaling proteins. Insulin Receptor, alpha (IRa) is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits. The alpha subunit (95kD) possesses a single transmembrane domain, whereas the beta-subunit is completely extracellular. The intracellular portion of the alpha subunit is a tyrosine-specific protein kinase with sequence homology to other such kinases. Activation of kinase is essential in signaling pathway whereby insulin regulates intracellular metabolism.

Additional Text

Gene Name

INSR

Uniprot ID

P06213

Gene ID

3643

Purification

Protein G purified

Antibody Clonality

Monoclonal

I7661-25D-ML650 Datasheet

Price

£1,038.00

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Quantity
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