Integrin alpha3, beta1 (CD49c, Very Late Antigen3a1b chain, VLA3a1b) (MaxLight 490)
Catalogue Number: I7661-33C-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 2Q993 (M-KID2) |
| Isotype: | IgG1 |
| Immunogen: | Human renal carcinoma cell line (KJ29). |
| Application: | FC, ICC, IP, RIA, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Integrins are a family of dimeric proteins that mediate cell-cell and extracellular matrix adhesion. Each VLA subtype (VLA-1, -2, -3, -4 and -5) is composed of a distinct alpha subunit noncovalently associated with a common beta subunit, as an alpha-beta dimer. Integrin VLA-3 (very late antigen, alpha 3/beta 1) is a cell surface receptor that binds to fibronectin, lamin, collagen type I and VI. VLA-3 is typically restricted in normal tissue but is widely expressed in many cultured tumor cells and correlates with the degree of invasiveness of malignant melanoma cells.
Additional Text
Gene Name
ITGA3
Uniprot ID
P26006
Gene ID
3675
Specificity
Recognizes human Integrin alpha3, beta1. Recognizes an epitope related to the VLA-3 complex (a3/b1 integrin). Specificity was determined by immunoprecipitation from a detergent extract of 35S-methionine labeled KJ29 cells.
Accession Number
NM_002204.1
Purification
Protein A purified
Antibody Clonality
Monoclonal
I7661-33C-ML490 Datasheet
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