Integrin alphaV, beta6 (MaxLight 550)
Catalogue Number: I7661-37W-ML550-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™550. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | 1110004F14Rik|2610028E01Rik|alpha v integrin|CD51|D430040G12Rik|integrin alpha-V|vitronectin receptor alpha polypeptide (VNRA)|vitronectin receptor subunit alpha |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 2Q871 (10D5) |
| Isotype: | IgG2a |
| Immunogen: | Immunization of beta6 knockout mice with wild type mouse keratinocytes. |
| Application: | FC, IP |
Description
Description: MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000. Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alphaV beta6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alphaV beta6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
Additional Text
Gene Name
ITGAV
Specificity
Recognizes mouse integrin alphaV beta6. Blocks activity against mouse and human alphaV beta6. Does not recognize alphaV or other alphaV integrins. Species Crossreactivity: human and rat. Because the antibody was raised in knockout mice, it is likely to recognize the receptor in other species.
Gene ID
16410
Purification
Protein A purified
Uniprot ID
P43406
Antibody Clonality
Monoclonal
I7661-37W-ML550 Datasheet
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