Interleukin 1 Receptor Type I (IL-1RI) (Carboxyfluorescein)

Catalogue Number: I7663-25G2-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS. Labeled with Carboxyfluorescein.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Rat
Clone:	7H42
Isotype:	IgG2b
Immunogen:	Recombinant mouse IL-1 RI extracellular domain.
Application:	FC

Overview
Datasheets

Description

Description: Two distinct types of receptors that bind the pleiotropic cytokines IL-1a and IL-1b have been described. The IL-1 receptor Type I is an 80kD transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1 receptor Type II is a 68kD transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Both receptors are members of the immunoglobulin superfamily and show approximately 28% sequence identity in their extracellular domains. The two receptor types do not heterodimerize into a receptor complex. An IL-1 receptor accessory protein (1) that can heterodimerize with the Type I receptor in the presence of IL-1a or IL-1b, but not IL-1ra, was identified. This Type I receptor complex appears to mediate all the known IL-1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL-1 signals. In addition to the membrane-bound form of IL-1 RII, a naturally-occurring soluble form of IL-1 RII has been described. It has been suggested that the Type II receptor, either as the membrane-bound or as the soluble form, serves as a decoy for IL-1 and inhibits IL-1 action by blocking the binding of IL-1 to the signaling Type I receptor complex. Recombinant IL-1 soluble receptor Type I is a potent antagonist of IL-1 action.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

IL1R1

Gene ID

16177

UniProt ID

P13504

Specificity

Recognizes mouse IL-1 RI.

Purification

Purified

Antibody Clonality

Monoclonal

I7663-25G2 Datasheet

Price

£630.00

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