Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin
Catalogue Number: ICH1085-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Ctla4, Cytotoxic T-lymphocyte protein 4, CD152 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Armenian Hamster |
| Clone: | UC10-4F10-11 |
| Isotype: | IgG1, kappa |
| Immunogen: | Purified Recombinant Mouse CTLA4 Fc Fusion Protein |
| Application: | FC, IP, WB, FA |
Description
Description: CD152, also known as CTLA-4 or Ly-56 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
Additional Text
Gene ID
12477
Gene Name
CTLA4
Uniprot ID
P09793
Caution
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Antibody Clonality
Monoclonal
Concentration
≥ 2 mg/ml
Application Notes
Functional Assay: Clone UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. Each investigator should determine their own optimal working dilution for specific applications.
Storage Note
anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is stable when stored at 2-8°C. Do not freeze.
Purification
This monoclonal antibody was purified using Protein A
ICH1085 Datasheet
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