Anti-Mouse CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11)

Catalogue Number: ICH1085-ICB

Manufacturer:IchorBio
Type:Monoclonal Primary Antibody - Unconjugated
Alias:Ctla4, Cytotoxic T-lymphocyte protein 4, CD152
Shipping Condition:Blue Ice
Unit(s): 100 mg, 25 mg, 5 mg, 50 mg
Host name: Armenian Hamster
Clone: UC10-4F10-11
Isotype: IgG1, kappa
Immunogen: Purified Recombinant Mouse CTLA4 Fc Fusion Protein
Application: FC, IP, WB, FA

Description

Description: CD152, also known as CTLA-4 or Ly-56 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.

Additional Text

Purification

Protein A/G Purified

Gene ID

12477

Gene Name

CTLA4

Uniprot ID

P09793

Caution

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Antibody Clonality

Monoclonal

Concentration

≥ 2 mg/ml

Application Notes

Functional Assay: Clone UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. Each investigator should determine their own optimal working dilution for specific applications.

Storage Note

anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is stable when stored at 2-8°C. Do not freeze.

Price
£2,539.00


Find out about delivery

SUPPORT

outstanding technical support

PRODUCT

we offer a full product guarantee

DELIVERY

we offer free delivery to UK universities and non profit organisations