Anti-Mouse IL-1R (JAMA-147) In Vivo Antibody - Low Endotoxin

Catalogue Number: ICH1117-ICB

Manufacturer:	IchorBio
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, CD121a
Shipping Condition:	Blue Ice
Unit(s):	100 mg, 25 mg, 5 mg, 50 mg
Host name:	Armenian Hamster
Clone:	JAMA-147
Isotype:	IgG
Immunogen:	Extracellular domain of mouse IL-1 R type 1
Application:	FC, IP, WB, Blk

Overview
Datasheets

Description

Description: IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1alpha and IL-1beta exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1alpha and IL-1beta, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.

Additional Text

Gene Name

IL1R1

Gene ID

16177

UniProt ID

P13504

Caution

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Concentration

1-5 mg/ml

Antibody Clonality

Monoclonal

Application Notes

Each investigator should determine their own optimal working dilution for specific applications.

Storage Note

anti-IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles

Purification

This monoclonal antibody was purified using Protein A

ICH1117 Datasheet

Price

£2,265.00

-

Quantity
Unit Size

Find out about delivery