Anti-Mouse PD-1 In Vivo Antibody - Low Endotoxin (RMP1-14)

Catalogue Number: ICH1132-ICB

Manufacturer:	IchorBio
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	Programmed cell death protein 1, Pdcd1, CD279
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	100 mg, 25 mg, 5 mg, 50 mg
Host name:	Rat
Clone:	RMP1-14
Isotype:	IgG2a, kappa
Immunogen:	Mouse PD-1 transfected BHK cells
Application:	FC, WB, FA, Blk

Overview
Datasheets

Description

Description: CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.

Additional Text

Gene Name

PDCD1

Purification

Protein A/G Purified

Gene ID

18566

Uniprot ID

Q02242

Caution

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Concentration

1-5 mg/ml

Antibody Clonality

Monoclonal

Application Notes

Blocking: Clone RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1. For immune checkpoint antibodies 200 ug per mouse per injection is the standard dosage in the literature. For this anti-PD-1 (clone RMP1-14), we suggest to inject 200 ug/mouse ip generally on days 3, 6 and 9, post injection of tumor. Sometime up to six injections depending on the length of the experiment may be required. Each investigator should determine their own optimal working dilution for specific applications.

Storage Note

anti-PD-1 In Vivo Antibody - Low Endotoxin (RMP1-14) is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -70oC.

ICH1132 Datasheet

Price

£2,393.00

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