Bulk Anti-Human CD195 (HEK/1/85a/7a) Antibody (CCR5)
Catalogue Number: ICH1172-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor, CD195 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Rat |
| Clone: | HEK/1/85a/7a |
| Isotype: | IgG2b, kappa |
| Immunogen: | CHO cells transfected with full-length human CD195 (CCR5). |
| Application: | FC, ICC |
Description
Description: CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection. CCR5 also contributes to other human diseases, including type I diabetes and cancer.
Additional Text
Gene Name
CCR5
Gene ID
1234
Uniprot ID
P51681
Antibody Clonality
Monoclonal
Application Notes
The suggested concentration for this CD195 antibody for staining cells in flow cytometry is ≤ 1.0 µg per 10^6 cells in a volume of 100 µl. Titration of the reagent is recommended for optimal performance for each application.
Concentration
≥ 5 mg/ml
Storage Note
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Purification
This monoclonal antibody was purified using Protein G
ICH1172 Datasheet
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