Bulk anti-Human CD195 (CCR5) antibody (HEK/1/85a/7a) [ICH1172]
Catalogue Number: ICH1172-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Rat |
| Clone: | HEK/1/85a/7a |
| Isotype: | IgG2b, kappa |
| Immunogen: | CHO cells transfected with full-length human CD195 (CCR5). |
| Application: | FC, ICC |
Description
Description: CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection. CCR5 also contributes to other human diseases, including type I diabetes and cancer.
Additional Text
Gene Name
CCR5
Gene ID
1234
Uniprot ID
P51681
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
The suggested concentration for this CD195 antibody for staining cells in flow cytometry is ≤ 1.0 µg per 10^6 cells in a volume of 100 µl. Titration of the reagent is recommended for optimal performance for each application.
Concentration
≥ 5 mg/ml
Storage Note
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
ICH1172 Datasheet
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