Anti-Mouse Fas Ligand (MFL3) In Vivo Antibody - Low Endotoxin

Catalogue Number: ICH1178-ICB

Manufacturer:	IchorBio
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	FasL, Apo-1 Ligand, CD95 Ligand, TNFSF6, CD178
Shipping Condition:	Blue Ice
Unit(s):	100 mg, 25 mg, 5 mg, 50 mg
Host name:	Armenian Hamster
Clone:	MFL3
Isotype:	IgG
Immunogen:	B6 mouse FasL cDNA-transfected baby hamster kidney (B6 FasL/BHK) cells
Application:	FC, IF, Blk

Overview
Datasheets

Description

Description: FasL antibody, clone AFS98, recognizes Fas ligand (FasL), also known as CD178, Apo-1 ligand, and CD95 ligand. FasL is a 40 kDa type II integral membrane protein that belongs to the tumor necrosis factor (TNF) superfamily. FasL is expressed by activated T cells and natural killer (NK cells). Binding of FasL to its receptor Fas (CD95, APO-1) induces apoptotic cell death in Fas-expressing target cells, contributing to anti-viral immunity. FasL also contributes to peripheral tolerance and the downregulation of immune responses through activation-induced autocrine and paracrine T cell death. FasL is also found in the anterior chamber of the eye and on Sertoli cells in the testis, and is implicated in immune-privilege at these sites. FasL also contributes to CD8 proliferation and neutrophil recruitment. Soluble FasL (26 kDa) can be released following cleavage by metalloproteinases and block FasL-mediated signaling. Fas/FasL-signaling is involved in the development of many human diseases, including autoimmunity and cancer. Many human tumors over-express FasL, resulting in tumor infiltrating lymphocyte (TIL) apoptosis and immune evasion, which is associated with poor prognosis.

Additional Text

Uniprot ID

P41047

Gene ID

14103

Gene Name

Fasl

Antibody Clonality

Monoclonal

Application Notes

The suggested concentration for this Fas Ligand antibody, clone MFL3, for staining cells in flow cytometry is ≤ 0.25 µg per 10^6 cells in a volume of 100 µl. Titration of the reagent is recommended for optimal performance for each application.

Concentration

≥ 5 mg/ml

Storage Note

This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Purification

This monoclonal antibody was purified using Protein A

ICH1178 Datasheet

Price

£2,265.00

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