Anti-Mouse Fas Ligand In Vivo Antibody - Low Endotoxin (MFL3)

Catalogue Number: ICH1178-ICB

Type:Monoclonal Primary Antibody - Unconjugated
Alias:FasL, Apo-1 Ligand, CD95 Ligand, TNFSF6, CD178
Shipping Condition:Blue Ice
Unit(s): 100 mg, 25 mg, 5 mg, 50 mg
Host name: Armenian Hamster
Clone: MFL3
Isotype: IgG
Immunogen: B6 mouse FasL cDNA-transfected baby hamster kidney (B6 FasL/BHK) cells
Application: FC, IF, Blk


Description: FasL antibody, clone AFS98, recognizes Fas ligand (FasL), also known as CD178, Apo-1 ligand, and CD95 ligand. FasL is a 40 kDa type II integral membrane protein that belongs to the tumor necrosis factor (TNF) superfamily. FasL is expressed by activated T cells and natural killer (NK cells). Binding of FasL to its receptor Fas (CD95, APO-1) induces apoptotic cell death in Fas-expressing target cells, contributing to anti-viral immunity. FasL also contributes to peripheral tolerance and the downregulation of immune responses through activation-induced autocrine and paracrine T cell death. FasL is also found in the anterior chamber of the eye and on Sertoli cells in the testis, and is implicated in immune-privilege at these sites. FasL also contributes to CD8 proliferation and neutrophil recruitment. Soluble FasL (26 kDa) can be released following cleavage by metalloproteinases and block FasL-mediated signaling. Fas/FasL-signaling is involved in the development of many human diseases, including autoimmunity and cancer. Many human tumors over-express FasL, resulting in tumor infiltrating lymphocyte (TIL) apoptosis and immune evasion, which is associated with poor prognosis.

Additional Text

Uniprot ID



Protein A/G Purified

Gene ID


Gene Name


Antibody Clonality


Application Notes

The suggested concentration for this Fas Ligand antibody, clone MFL3, for staining cells in flow cytometry is ≤ 0.25 µg per 10^6 cells in a volume of 100 µl. Titration of the reagent is recommended for optimal performance for each application.


≥ 5 mg/ml

Storage Note

This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.


Find out about delivery


outstanding technical support


we offer a full product guarantee


we offer free delivery to UK universities and non profit organisations