Bulk anti-Human CXCR4 Antibody (12G5) [ICH1199]
Catalogue Number: ICH1199-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Fusin, LESTR, CD184 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Mouse |
| Clone: | 12G5 |
| Isotype: | IgG2a, kappa |
| Immunogen: | 12G5 was produced by immunizing Balb/c mice with CP-MAC-infected Sup-T1 cells. Hybridomas were generated and screened for the ability to inhibit CP-MAC-induced syncytium induction on Sup-T1 cells. |
| Application: | FC, ICC, IF, WB, IHC, NT, Blk |
Description
Description: 12G5 binds specifically to both human and nonhuman cells that express recombinant CXCR4. 12G5 inhibits CD4-independent infection by some HIV-2 isolates, and preincubating cells with 12G5 abolishes syncytium formation. HIV-2/vcp-infected cells display a marked and selective reduction in 12G5 binding. 12G5 also inhibits induction of cell-to-cell fusion of CXCR4+ RD/CD4 cells by HIV-1 and HIV-2 strains.
Additional Text
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
Each investigator should determine their own optimal working dilution for specific applications.
Concentration
≥ 2 mg/ml
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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