Anti-Mouse CD183 (CXCR3-173) In Vivo Antibody - Low Endotoxin
Catalogue Number: ICH1201-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | CXCR3G, protein-coupled receptor 9 (GPR9), CKR-L2, IP10 receptor (IP10-R), Mig receptor (Mig-R ), CD183 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Armenian Hamster |
| Clone: | CXCR3-173 |
| Isotype: | IgG |
| Immunogen: | CXCR3-173 was generated by immunizing Armenian hamsters with a peptide sequence unique to mouse CXCR3 which encompasses amino acids 1-37. |
| Application: | FC, NT |
Description
Description: Hamsters were tested by ELISA for seropositivity against CXCR3 peptide and hybridomas were generated, screened by FACS, purified, and tested for: staining, CXCR3 blockade in vitro, and endotoxin levels. CXCR3-173 detects the native form of CXCR3, and therefore does not work in Western blotting. CXCR3-173 has potential use in immunotherapeutic approaches to inhibit transplant rejection and immune related diseases. In vitro, CXCR3-173 blocks chemotaxis in response to CXCL10 or CXCL11 but not CXCL9. In vivo, CXCR3-173 prolongs both cardiac and islet allograft survival in a manner further enhanced by rapamycin.
Additional Text
Antibody Clonality
Monoclonal
Application Notes
Each investigator should determine their own optimal working dilution for specific applications.
Concentration
≥ 2 mg/ml
Storage Note
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Purification
This monoclonal antibody was purified using Protein A
Endotoxin
<1.0 EU/mg as determined by the LAL method
ICH1201 Datasheet
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