Atibuclimab Biosimilar - Research Grade [ICH5016]
Catalogue Number: ICH5016-ICB
| Manufacturer: | IchorBio |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 20 mg, 5 mg, 50 mg, 1 mg, 100 mg |
| Host name: | |
| Clone: | |
| Isotype: | IgG4 |
| Immunogen: | |
| Application: | FA |
Description
Description: RUO atibuclimab is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. It acts as a pattern recognition receptor for bacterial cell wall components in gram-positive and negative bacteria. CD14 antibody action stimulates a pro-inflammatory cytokine cascade often associated with inflammation in sepsis. Atibuclimab neutralization of this antibody results in the inhibition of TNF-a, IL-6 and IL-10, dampening systemic inflammatory responses. Atibuclimab also delays the release of sTNFR(1) and IL-1ra.
Additional Text
Gene Name
CD14
Concentration
5 mg/ml
Gene ID
929
Purification
Protein A/G Purified
Uniprot ID
P08571
Antibody Clonality
Recombinant Monoclonal
Application Notes
This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Storage Note
This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
ICH5016 Datasheet
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations