Human IDH1 Protein (IDH-HE101)
Catalogue Number: IDH-HE101-KAT
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 47.35 kDa same as Bis-Tris PAGE result. |
| Physical state: | Liquid |
| Type: | Other Recombinant Protein |
| Alias: | IDH; IDH1; IDPc; PICD; IDP; DCD; IDH; Isocitrate dehydrogenase; IDCD |
| Host Cell: | E.coli |
| Shipping Condition: | Dry Ice |
| Unit(s): | 100 ug, 500 ug |
| Application: | WB |
Description
Description: Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG). Genetic gain-of-function mutations in IDH1 and IDH2 confer a neomorphic activity that allow reduction of α -KG to (R)-2- hydroxyglutarate, the accumulation of which results in the development of cancers like low grade gliomas and leukemia.Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer.
Additional Text
Gene Name
IDH1
Gene ID
3417
Uniprot ID
O75874
Protein Tag
HIS Tag
Short Description
Recombinant Human IDH1 Protein is expressed from E.coli with His tag at the C-Terminus.It contains Ser2-Leu414.
Storage Note
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Endotoxin
Less than 1 EU per µg by the LAL method.
IDH-HE101 Datasheet
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