Mouse PCNA Ready-To-Use IHC Kit

Catalogue Number: IHC0123M-BSS

Manufacturer:	Bioss Inc
Shelf Life:	6 months
Type:	IHC kits
Alias:	Cyclin\|DNA polymerase delta auxiliary protein\|HGCN8729\|MGC8367\|Mutagen-sensitive 209 protein\|Pcna/cyclin\|PCNAR\|Polymerase delta accessory protein\|Proliferating Cell Nuclear Antigen.
Shipping Condition:	Blue Ice
Unit(s):	50 tests
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Sample type:	FFPE Tissue
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Application:	IHC

Overview
Datasheets

Description

Description: PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.

Additional Text

Storage Note

Storage and Stability: Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.

IHC0123M Datasheet

Price

£416.00

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