Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein (ITG-HM12B)
Catalogue Number: ITG-HM12B-KAT
ITG-HM12B Image
ITG-HM12B Image
ITG-HM12B Image
ITG-HM12B Image
The purity of Human ITGA2B&ITGB3 is greater than 95% as determined by SEC-HPLC.
ITG-HM12B Image
Human ITGA2B&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
ITG-HM12B Image
Immobilized Abciximab at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ITGA2B&ITGB3, His Tag with the EC50 of 16.7ng/ml determined by ELISA.
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 110.5 kDa (ITGA2B)&81.3 kDa (ITGB3). Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result. |
| Physical state: | Lyophilized |
| Type: | Intergrins |
| Alias: | α2Bβ3; ITGA2B&ITGB3; ITGA2B; ITGB3 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | WB |
Description
Description: Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.
Additional Text
Protein Tag
HIS Tag
UniProt ID
P05106-1
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Endotoxin
Less than 1 EU per µg by the LAL method.
Short Description
Recombinant Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus of ITGA2B.It contains Leu32-Arg993(ITGA2B) acidic tail and GLy27-Asp718(ITGB3) basic tail.
ITG-HM12B Datasheet
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