Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-HM4V8)
Catalogue Number: ITG-HM4V8-KAT
ITG-HM4V8 Image
ITG-HM4V8 Image
ITG-HM4V8 Image
ITG-HM4V8 Image
ITG-HM4V8 Image
The purity of Human ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC.
ITG-HM4V8 Image
Human ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
ITG-HM4V8 Image
Immobilized Human ITGAV&ITGB8, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.85 ug/ml determined by ELISA (QC Test).
ITG-HM4V8 Image
Immobilized Human ITGAV&ITGB8, His Tag at 2ug/ml(100ul/well) on the plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA.
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 114 kDa (ITGAV) and 76 kDa (ITGB8). Due to glycosylation, the protein migrates to 90-150 kDa based on Bis-Tris PAGE result. |
| Physical state: | Lyophilized |
| Type: | Intergrins |
| Alias: | αVβ8; Integrin alpha V beta 8; TGAV&ITGB8;Integrin alpha V β 8 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | ELISA, WB |
Description
Description: Integrin αVβ8 is a heterodimeric cell surface receptor involved in various cellular processes, including cell adhesion, migration, and signaling. It is recognized for its unique role in activating TGF-β and has been implicated in immune responses and tissue homeostasis. Due to its distinctive structure and function, integrin αVβ8 is considered atypical among integrin family members.
Additional Text
Protein Tag
HIS-AviTag™
UniProt ID
P06756-1
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biological Activity
Immobilized Human ITGAV&ITGB8, His Tag at 5Oeg/ml (100Oel/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.39ug/ml determined by ELISA. See testing image for detail.
Endotoxin
Less than 1 EU per µg by the LAL method.
Short Description
Recombinant Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGAV.It contains Phe31-Val992(ITGAV) acidic tail and Glu43-Arg684(ITGB8) basic tail.
ITG-HM4V8 Datasheet
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