Rhesus macaque Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-RM1V6)
Catalogue Number: ITG-RM1V6-KAT
ITG-RM1V6 Image
ITG-RM1V6 Image
ITG-RM1V6 Image
ITG-RM1V6 Image
ITG-RM1V6 Image
ITG-RM1V6 Image
The purity of Rhesus macaque ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.
ITG-RM1V6 Image
Rhesus macaque ITGAV&ITGB6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
ITG-RM1V6 Image
Immobilized Rhesus macaque ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 37.6ng/ml determined by ELISA (QC Test).
ITG-RM1V6 Image
Immobilized Rhesus macaque ITGAV&ITGB6, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha-V Antibody, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA.
ITG-RM1V6 Image
Immobilized Rhesus macaque ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGB6 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA.
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 112.1 kDa (ITGAV) and 79 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-140 kDa based on Bis-Tris PAGE result. |
| Physical state: | Lyophilized |
| Type: | Intergrins |
| Alias: | αVβ6; ITGAV&ITGB6;Integrin alpha V beta 6;Integrin alpha V β 6 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | ELISA, WB |
Description
Description: ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Additional Text
Gene Name
ITGB6
Protein Tag
HIS Tag
Gene ID
700454
Uniprot ID
A0A1D5QZT0, F6QSK2
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Short Description
Recombinant Rhesus macaque Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Pro993 (ITGAV) acidic tail and Gly22-Asn707 (ITGB6) basic tail.
Biological Activity
Immobilized Rhesus macaque ITGAV&ITGB6, His Tag at 5Oeg/ml (100Oel/well) on the plate. Dose response curve for Anti-alpha-V Antibody, hFc Tag with the EC50 of 32.4ng/ml determined by ELISA. See testing image for detail.
Endotoxin
Less than 1 EU per µg by the LAL method.
ITG-RM1V6 Datasheet
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