Jagged1 (JAG1, AGS, AHD, AWS, HJ1, JAGL1, Alagille Syndrome Protein, CD339, Headturner, Htu, Serrate-1, Ser-1, Slalom) (Carboxyfluorescein)

Catalogue Number: J0400-01J-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 1ml saline, 0.5% BSA, 0.09% sodium azide. Labeled with Carboxyfluorescein (CFS).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	11n115
Isotype:	IgG2b
Immunogen:	Recombinant corresponding to Ser32-Asp296 from human Jagged 1 expressed in NSO cells.
Application:	FC

Overview
Datasheets

Description

Description: Jagged 1-CFS was the first ligand for Notch identified in mammals. Since both the ligands and the receptors are transmembrane proteins, direct cell-cell interactions are thought to be required for activating Notch signaling. Its large extracellular region has a DSL (Delta, Serrate, Lag-2 consensus sequence) domain followed by 16 EGF-like repeats, and a cysteine-rich (CR) region. The DSL motif is necessary for binding to Notch receptors and the EGF repeats modulate the affinity of the interaction with Notch receptors. Notch signaling is implicated in many developmental processes in a variety of cell types. Jagged-Notch signaling specifies cell fate, regulates pattern formation, defines boundaries between different cell types, and modulates cell proliferation and differentiation. Some specific areas where Jagged is involved include hematopoiesis, myogenesis, neurogenesis, and development of the vasculature. Furthermore, Jagged 1 mutations are implicated in Alagille syndrome, an autosomal dominant disorder characterized by defects in liver, heart, kidney, eye, skeletal, craniofacial tissues.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene ID

182

Gene Name

JAG1

Uniprot ID

P78504

Specificity

Recognizes human Jagged 1. Does not recognize recombinant human Jagged 2. Stains human Jagged 1 transfectants but not the parental cell line or human Jagged 2 transfectants in Flow Cytometry. Species Crossreactivity: mouse and rat

Purification

Protein G purified

Antibody Clonality

Monoclonal

J0400-01J Datasheet

Price

£664.00

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