Anti-Phospho-RAF1-S259 Polyclonal Antibody
Catalogue Number: K006222P-SLB
| Manufacturer: | SolarBio |
| Shelf Life: | 12 months |
| Molecular Weight: | 73kDa |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S259 of human RAF1 |
| Application: | IP, WB |
Description
Description: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Additional Text
Gene ID
5894
Gene Name
RAF1
Uniprot ID
P04049
Purification
Affinity Purified
Molecular Weight
73kDa
Antibody Clonality
Polyclonal
Storage Note
Store at -20°C. Avoid freeze/thaw cycles. 1 Year
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