Anti-CD158D Polyclonal antibody

Catalogue Number: K009907P-SLB

Manufacturer:	SolarBio
Shelf Life:	12 months
Molecular Weight:	39kda
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 50 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	KLH conjugated synthetic peptide derived from human CD158:51-150/377
Application:	ELISA, IF, IHC-P, WB, IHC-Fr

Overview

Description

Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the framework loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Additional Text

Molecular Weight

39kDa

Gene ID

3805

Gene Name

KIR2DL4

Uniprot ID

Q99706

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Storage Note

Store at -20°C. Avoid freeze / thaw cycles. 1 Year

Price

£487.00

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