Anti-MHC Class II(FITC) Monoclonal Antibody
Catalogue Number: K010130M-SLB
| Manufacturer: | SolarBio |
| Shelf Life: | 12 months |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rat |
| Clone: | |
| Isotype: | IgG2b |
| Immunogen: | Activated C57BL/6 mouse spleen cells |
| Application: | FC |
Description
Description: Major histocompatibility complex (MHC) class II molecules are heterodimeric transmembrane glycoproteins that are expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells. The M5/114.15.2 antibody detects polymorphic determinants present on B cells, monocytes, macrophages, dendritic cells, and activated T lymphocytes from mice carrying the H-2b, H-2d, H-2q, H-2p, H-2r and H-2u haplotypes but not from mice carrying the H-2s or H-2f haplotypes (PMID: 6170707). This antibody recognizes both I-A and I-E subregion-encoded Ia glycoproteins (I-Ab, I-Ad, I-Aq, I-Ed, I-Ek, not I-Af, I-Ak, or I-As). M5/114 mAb is reported to inhibit I-A subregion-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not the H-2f, H-2k, H-2s haplotypes (PMID: 6173436).
Additional Text
Purification
Affinity Purified
Gene ID
14960
UniProt ID
P14434
Antibody Clonality
Monoclonal
Gene Name
H2-Aa
Storage Note
Store at 2-8°C. Avoid exposure to light. 1 Year
SUPPORT
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DELIVERY
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