Anti-Phospho-PERK (Thr982) Polyclonal Antibody
Catalogue Number: K010157P-SLB
| Manufacturer: | SolarBio |
| Shelf Life: | 12 months |
| Molecular Weight: | 125kDa |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human Phospho-PERK (Thr982) |
| Application: | ELISA, ICC, IF, WB, IHC |
Description
Description: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Additional Text
Gene Name
EIF2AK3
Uniprot ID
Q9NZJ5
Gene ID
9451
Molecular Weight
125kDa
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Storage Note
Store at -20°C. Avoid freeze / thaw cycles. 1 Year
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DELIVERY
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