Anti-CD8a(AF647) Monoclonal Antibody
Catalogue Number: K011469M-SLB
| Manufacturer: | SolarBio |
| Shelf Life: | 12 months |
| Molecular Weight: | 27kDa |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rat |
| Clone: | |
| Isotype: | IgG2a, kappa |
| Immunogen: | Spleen cells or thymocyte membranes |
| Application: | IF |
Description
Description: CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains.It can be present as a homodimer of CD8 or as a heterodimer of CD8 and CD8 (PMID: 3264320;8253791).CD8 is found on most thymocytes.The majority of class I-restricted T cells express mostly the CD8 heterodimer while CD8 homodimers alone have been found on some gut intraepithelial T cells on some T cell receptor (TCR) T cells and on NK cells (PMID: 2111591;1831127;8420975).CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079).During T cell development CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084).
Additional Text
Molecular Weight
27kDa
Gene Name
CD8A
Gene ID
12525
Uniprot ID
P01731
Purification
Affinity Purified
Antibody Clonality
Monoclonal
Storage Note
Store at 2-8°C in dark.Do not freeze. 1 Year
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations