Sheep anti Human chk 1 kinase
Catalogue Number: K100P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | sheep anti human chk 1 kinase, checkpoint kinase 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | |
| Application: | IP, WB |
Description
Description: One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2.
Additional Text
Gene Name
CHEK1
Gene ID
1111
Uniprot ID
O14757
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Western Blot at 1 - 10 ug/ml.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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