Sheep anti Human Vesicle Associated Membrane Protein (VAMP 1/2)
Catalogue Number: K105P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | Sheep anti vesicle associated membrane protein 1 and 2, VAMP 1 and 2, VAMP1/2, VAMP 1/2, VAMP-1/2; Synaptobrevin 1 and 2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Full length VAMP1/2 protein |
| Application: | IP, WB |
Description
Description: Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.
Additional Text
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Applications: Western Blotting, Immunoprecipitation
Uniprot ID
O35619
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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