Anti-SMAD2 Polyclonal Antibody

Catalogue Number: K115630P-SLB

Manufacturer:	SolarBio
Shelf Life:	12 months
Molecular Weight:	49/52kDa
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 20 ul, 50 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	A synthetic peptide of human SMAD2
Application:	WB

Overview

Description

Description: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Additional Text

Gene Name

SMAD2

Gene ID

4087

Uniprot ID

Q15796

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Storage Note

Store at -20°C. Avoid freeze / thaw cycles. 1 Year

Molecular Weight

49/52kDa

Price

£223.00

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