Anti-MECP2 Polyclonal Antibody
Catalogue Number: K115659P-SLB
| Manufacturer: | SolarBio |
| Shelf Life: | 12 months |
| Molecular Weight: | 52/53kDa |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul, 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human MECP2 |
| Application: | WB |
Description
Description: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms.
Additional Text
Gene Name
MECP2
Gene ID
4204
Uniprot ID
P51608
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Storage Note
Store at -20°C. Avoid freeze / thaw cycles. 1 Year
Molecular Weight
52/53kDa
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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