Sheep anti Human Guanalyate Kinase GKWW domain (MAGI)
Catalogue Number: K115P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | Sheep anti-Membrane-associated guanylate cyclase of inverted orientation-3, Guanylate Kinase-WW domains |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant protein corresponding to the guanylate kinase-WW domain of MAGI-3. |
| Application: | WB |
Description
Description: Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is then followed by 6 PDZ domains.
Additional Text
Gene ID
260425
Gene Name
MAGI3
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Antibody detects MAGI-3 by Western blot at 1-10 µg/ml. Detects a 130 kDa band in cells transfected with full-length MAGI-3 protein. Optimal concentration should be evaluated by serial dilutions.
Uniprot ID
Q9H2V6
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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