KLRG1 (Killer Cell Lectin-like Receptor G1, MAFA, 2F1-Ag) (FITC)
Catalogue Number: K1893-18A-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with FITC. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 500 ug |
| Host name: | Hamster |
| Clone: | 5K32 |
| Isotype: | IgG |
| Immunogen: | Activated NK (A-LAK) cells from B6 (H-2b) mice. |
| Application: | FC, IP |
Description
Description: Killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA or 2F1-Ag) is a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Recognizes mouse killer cell lectin-like receptor G1 (KLRG1, Mr 30-38kD).
Purification
Purified
Antibody Clonality
Monoclonal
K1893-18A Datasheet
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