Biotinylated Human Kallikrein 5/KLK5 Protein (active form) (KLK-HM405B)

Catalogue Number: KLK-HM405B-KAT

Manufacturer:	Kactus
Shelf Life:	12 months
Molecular Weight:	The protein has a predicted MW of 32.51 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Physical state:	Lyophilized
Type:	Proteases
Alias:	Kallikrein c; Klnc; KLK5; KLKL2; KLK-L2; SCTE
Host Cell:	HEK293 cells
Shipping Condition:	RT
Unit(s):	100 ug, 500 ug

Overview
Datasheets

Description

Description: The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.

Additional Text

Gene Name

KLK5

Gene ID

25818

Uniprot ID

Q9Y337

Protein Tag

HIS-AviTag™

Storage Note

-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Endotoxin

Less than 1 EU per µg by the LAL method.

Short Description

Recombinant Biotinylated Human Kallikrein 5/KLK5 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Ile67-Ser293.

KLK-HM405B Datasheet

KLK-HM405B MSDS

Price

£413.00

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Quantity
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