Senescence β-Galactosidase Staining Kit

Catalogue Number: KTA3030-ABK

Manufacturer:Abbkine
Type:Cell Proliferation / Viability Assays
Alias:Cell Senescence; β-Galactosidase Staining Kit
Shipping Condition:Blue Ice
Unit(s): 100 T

Description

Description: Cells are the basic unit of biological structure and function, as well as the basic unit of biological aging. Cellular senescence is morphologically manifested as degeneration of cell structure, such as nuclear membrane depression, which eventually leads to nuclear membrane collapse, chromatin structure changes, and the number of hyperdiploid and abnormal polyploid cells increases; cell membrane fragility increases. Sexual permeability decreases, and the types and numbers of membrane receptors and the sensitivity to ligands change; lipofuscin accumulates in cells, and many organelles and intracellular structures undergo degeneration. Cell senescence is physiologically manifested as functional decline and low metabolism, such as cell cycle arrest, loss of cell replication ability, weakened responsiveness to mitogenic stimulation, and changes in responsiveness to pro-apoptotic factors; intracellular enzyme active centers are oxidized , Enzyme activity decreased, protein synthesis decreased, etc. The senescent cells can no longer replicate, but they still maintain metabolically active and stain positive for senescence-associated beta-galactosidase activity, which is considered to be a biomarker of cellular senescence.

Additional Text

Short Description

Senescence β-galactosidase staining kit provides a simple and convenient operation method for staining detection of senescent cells or tissues; This kit only stains senescent cells, and does not stain pre-senescence cells (senescent cells), quiescent cells (static cells), immortal cells (immortal cells) or tumor cells.