LAG-3 (Lymphocyte Activation Gene-3, FDC Protein, CD223) (MaxLight 490)
Catalogue Number: L1050-61F-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rat |
| Clone: | 7E155 (C9B7W) |
| Isotype: | IgG1 |
| Immunogen: | Murine CD223 Ig fusion protein |
| Application: | FC |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Murine lymphocyte activation gene-3 (LAG-3) is a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion.
Additional Text
Gene Name
LAG3
Specificity
Recognizes murine lymphocyte activation gene-3 (LAG-3). Recognizes an epitope within the D2 domain of CD223. Reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II.
Purification
Protein G purified
Uniprot ID
Q61790
Gene ID
16768
Antibody Clonality
Monoclonal
L1050-61F-ML490 Datasheet
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