Mouse anti Human NGF (Nerve Growth Factor)

Catalogue Number: L146M-EXA

Manufacturer:	ExAlpha
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	NGF, hNGF, Beta-nerve growth factor, Beta-NGF, NGF, NGFB
Shipping Condition:	Blue Ice
Unit(s):	500 ug
Host name:	Mouse
Clone:	AS18
Isotype:	IgG1
Immunogen:
Application:	IP, EIA, Inh-Fun

Overview

Description

Description: Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. Recently, it has been shown that cells which do not normally respond to NGF only express low affinity receptors from transfected NGF genes but cells which normally are NGF-responsive express high affinity receptors from the same NGF sequences. This supports the hypothesis that the high affinity receptors have a unique component in addition to the subunit common to the low affinity receptors.

Additional Text

Uniprot ID

P01138

Gene Name

NGF

Gene ID

4803

Purification

Protein A/G Purified

Antibody Clonality

Monoclonal

Storage Note

Store at -20C. Aliquot to avoid freeze/thaw cycles

Application Notes

Antibody can be used for immunoprecipitation, EIA and for neutralizing NGF in functional studies. Optimal concentration should be evaluated by serial dilutions.

Price

£355.00

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